The role of radiotherapy in the management of localized soft tissue sarcomas
Identifieur interne : 000995 ( Main/Exploration ); précédent : 000994; suivant : 000996The role of radiotherapy in the management of localized soft tissue sarcomas
Auteurs : Siaw Sze Tiong [Canada] ; Colleen Dickie [Canada] ; Rick L. Haas [Pays-Bas] ; Brian O Ullivan [Canada]Source :
- Cancer Biology & Medicine [ 2095-3941 ] ; 2016.
Abstract
The combination of radiotherapy (RT) and function-preserving surgery is the most usual contemporary approach in the management of soft tissue sarcomas (STS). Pre- and postoperative RT result in similar local control rates, as shown by a landmark trial in extremity STS. In this review, the role of RT in the management of extremity STS will be discussed, but STS in other sites, including retroperitoneal STS, will also be addressed. The focus will consider various aspects of RT including strategies to reduce the volume of tissue being irradiated, dose, scheduling, and the possible of omission of RT in selected cases. Finally, technology advances through the use of intensity-modulated radiotherapy (IMRT), image-guided IMRT, intraoperative radiotherapy (IORT) and particle therapy will also be discussed.
Url:
DOI: 10.20892/j.issn.2095-3941.2016.0028
PubMed: 27807504
PubMed Central: 5069839
Affiliations:
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Haas</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam 1066, CX, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam 1066, CX</wicri:regionArea><wicri:noRegion>CX</wicri:noRegion></affiliation></author><author><name sortKey="O Ullivan, Brian" sort="O Ullivan, Brian" uniqKey="O Ullivan B" first="Brian" last="O Ullivan">Brian O Ullivan</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Department of Radiation Oncology, Princess Margaret Cancer Center, University of Toronto, Toronto M5G 2M9, ON, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Radiation Oncology, Princess Margaret Cancer Center, University of Toronto, Toronto M5G 2M9, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><title level="j">Cancer Biology & Medicine</title><idno type="ISSN">2095-3941</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The combination of radiotherapy (RT) and function-preserving surgery is the most usual contemporary approach in the management of soft tissue sarcomas (STS). Pre- and postoperative RT result in similar local control rates, as shown by a landmark trial in extremity STS. In this review, the role of RT in the management of extremity STS will be discussed, but STS in other sites, including retroperitoneal STS, will also be addressed. The focus will consider various aspects of RT including strategies to reduce the volume of tissue being irradiated, dose, scheduling, and the possible of omission of RT in selected cases. 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Eide</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>Pays-Bas</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Tiong, Siaw Sze" sort="Tiong, Siaw Sze" uniqKey="Tiong S" first="Siaw Sze" last="Tiong">Siaw Sze Tiong</name></region><name sortKey="Dickie, Colleen" sort="Dickie, Colleen" uniqKey="Dickie C" first="Colleen" last="Dickie">Colleen Dickie</name><name sortKey="O Ullivan, Brian" sort="O Ullivan, Brian" uniqKey="O Ullivan B" first="Brian" last="O Ullivan">Brian O Ullivan</name></country><country name="Pays-Bas"><noRegion><name sortKey="Haas, Rick L" sort="Haas, Rick L" uniqKey="Haas R" first="Rick L." last="Haas">Rick L. 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